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Details for messenger / hormone: VEGF-121

EndoNet ID: ENH00761

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Synonyms

  • vascular permeability factor
  • vascular endothelial growth factor A
  • VEGF-121
  • VEGF121
  • VEGF(121)

General information

  • The freely diffusible VEGF-121 is an acidic polypeptide that does not bind heparin. [1]
  • VEGF(121) and VEGF(165) induced by hypoxia have different functions on coronary vascular growth. [2]
  • Regulates blood vessel diameter. [3]
  • VEGF(121) signals through VEGF receptor 2 (VEGFR-2). [3]
  • Neuropilin-1 and neuropilin-2 enhance VEGF121 stimulated signal transduction by the VEGFR-2 receptor. [4]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • PDGF/VEGF growth factor family

      Composition

      Sequence 
      APMAEGGGQ NHHEVVKFM DVYQRSYCH 
PIETLVDIF QEYPDEIEY IFKPSCVPL 
MRCGGCCND EGLECVPTE ESNITMQIM 
RIKPHQGQH IGEMSFLQH NKCECRPKK 
DRARQENCD KPRR

      Links to other resources

      UniProt P15692-7
      Ensembl ENST00000372055
      KEGG hsa:7422

      • Anatomical structure: hepatocyte

        • VEGF-121, VEGF-165 and VEGF-189 were detected in 14 of the 15 HCC samples and in all the corresponding non-cancerous tissue samples. [5]

      Targets

      CellVascular endothelial growth factor receptor 1Vascular endothelial growth factor receptor 2
      bone marrow Present
      Phenotypes
      • hematopoiesis
      		Present
      Phenotypes
      • angiogenesis
      brain Present
      continuous vascular endothelial cell of blood vessels and lymphatics Present
      Phenotypes
      • regulation of angiogenesis
      • positive regulation of endothelial cell proliferation
      • positive regulation of endothelial cell migration
      • inflammation
      Influences
      • ↑ interleukin 6
      		Present
      Influences
      • ↓ VEGF-165
      heart Present
      Phenotypes
      • heart development
      kidney Present
      lung Present
      microvascularendothelial cell Present
      Influences
      • ↑ von Willebrand factor
      Müllers radial cell of retina Present
      Phenotypes
      • regulation of neural retina development
      		Present
      Phenotypes
      • regulation of neural retina development
      placenta Present
      Phenotypes
      • preeclampsia
      sinusoidal endothelial cell Present
      Phenotypes
      • negative regulation of apoptosis
      		Present
      Phenotypes
      • regulation of endothelial cell differentiation
      smooth muscle Present
      Phenotypes
      • vessel maturation
      vascularendothelial cell Present
      Phenotypes
      • vasculogenesis
      • vascular permeability
      Reference