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Details for messenger / hormone: pancreastatin

EndoNet ID: ENH00768

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Synonyms

  • vasostatin II
  • vasostatin I
  • pituitary secretory protein I
  • Chromogranin-A
  • pancreastatin

General information

  • Pancreastatin is elevated in diabetes, and the variant Gly297Ser had increased potency to inhibit glucose uptake. [1]
  • After cleavage from CHGA, pancreastatin requires carboxyl-terminal amidation by the peptide alpha-amidating monooxygenase (PAM) for activation. [1]
  • The qualitative hereditary alterations of the primary structure in pancreastatin give rise to interindividual differences in glucose disposition. [2]
  • CgA specifically acts as the master "on/off" switch regulating secretory granule formation in neuroendocrine cells. [3]

Classification

Hormone function

  • metabolism
    • nutrient supply

    Chemical classification

    • hormone
      • genome-encoded
        • chromogranin/secretogranin family

      Composition

      pancreastatin, peptide

      • Pancreastatin strongly inhibits glucose induced insulin release from the pancreas. [4]
      Sequence 
      SEALAVDGA GKPGAEEAQ DPEGKGEQE 
HSQQKEEEE EMAVVPQGL FRG

      Links to other resources

      UniProt P10645
      Ensembl ENST00000216492
      KEGG hsa:1113

      • Anatomical structure: enterochromaffin_like_cell

      Targets

      Cell
      No records found.
      Reference