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Details for messenger / hormone: chromogranin A

EndoNet ID: ENH00771

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Synonyms

  • vasostatin II
  • vasostatin I
  • Chromogranin-A
  • CHGA
  • chromogranin A
  • CgA
  • pituitary secretory protein I
  • SP-I

General information

  • Chromogranin A is an acidic glycoprotein, which is widely expressed in endocrine and neuroendocrine cells. [1]
  • Cga acts as host defense peptides in the first phase of microbial invasions. [2]
  • Cga and its derived peptides play multiple roles in the endocrine, cardiovascular, and nervous systems. [3]
  • Helper protein in packing other proteins into secretory granules. [4]
  • CgA specifically acts as the master "on/off" switch regulating secretory granule formation in neuroendocrine cells. [5]

Classification

Hormone function

  • homeostasis
    • cardiovascular control
    • immune response
      • activation

      Chemical classification

      • hormone
        • genome-encoded
          • chromogranin/secretogranin family

        Composition

        chromogranin A, chain

        Sequence 
        LPVNSPMNK GDTEVMKCI VEVISDTLS 
KPSPMPVSQ ECFETLRGD ERILSILRH 
QNLLKELQD LALQGAKER AHQQKKHSG 
FEDELSEVL ENQSSQAEL KEAVEEPSS 
KDVMEKRED SKEAEKSGE ATDGARPQA 
LPEPMQESK AEGNNQAPG EEEEEEEEA 
TNTHPPASL PSQKYPGPQ AEGDSEGLS 
QGLVDREKG LSAEPGWQA KREEEEEEE 
EEAEAGEEA VPEEEGPTV VLNPHPSLG 
YKEIRKGES RSEALAVDG AGKPGAEEA 
QDPEGKGEQ EHSQQKEEE EEMAVVPQG 
LFRGGKSGE LEQEEERLS KEWEDSKRW 
SKMDQLAKE LTAEKRLEG QEEEEDNRD 
SSMKLSFRA RAYGFRGPG PQLRRGWRP 
SREEDSLEA GLPLQVRGY PEEKKEEEG 
SANRRPEDQ ELESLSAIE AELEKVAHQ 
LQALRRG

        Links to other resources

        UniProt P10645
        Ensembl ENST00000216492
        KEGG hsa:1113

        • Anatomical structure: basophil_gonadotroph_cell_of_anterior_pituitary_FSH

          Influenced by:

          • gonadotropin-releasing hormone receptor
            in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
            • CgA secretion was maintained by GnRH and reduced below control levels by transfer to activin only. [6]

        Targets

        Cell
        No records found.
        Reference