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Details for messenger / hormone: secretogranin-2

EndoNet ID: ENH00773

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Synonyms

  • Chromogranin-C
  • secretogranin-2
  • SCG2
  • secretogranin II
  • SgII
  • chromogranin C
  • ProSN

General information

  • Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides. [1]
  • Helper protein in packing other proteins into secretory granules. [2]

Classification

Hormone function

  • homeostasis
    • further hormone secretion

    Chemical classification

    • hormone
      • genome-encoded
        • chromogranin/secretogranin family

      Composition

      secretogranin-2, chain

      Sequence 
      QRNQLLQKE PDLRLENVQ KFPSPEMIR 
ALEYIENLR QQAHKEESS PDYNPYQGV 
SVPLQQKEN GDESHLPER DSLSEEDWM 
RIILEALRQ AENEPQSAP KENKPYALN 
SEKNFPMDM SDDYETQQW PERKLKHMQ 
FPPMYEENS RDNPFKRTN EIVEEQYTP 
QSLATLESV FQELGKLTG PNNQKRERM 
DEEQKLYTD DEDDIYKAN NIAYEDVVG 
GEDWNPVEE KIESQTQEE VRDSKENIG 
KNEQINDEM KRSGQLGIQ EEDLRKESK 
DQLSDDVSK VIAYLKRLV NAAGSGRLQ 
NGQNGERAT RLFEKPLDS QSIYQLIEI 
SRNLQIPPE DLIEMLKTG EKPNGSVEP 
ERELDLPVD LDDISEADL DHPDLFQNR 
MLSKSGYPK TPGRAGTEA LPDGLSVED 
ILNLLGMES AANQKTSYF PNPYNQEKV 
LPRLPYGAG RSRSNQLPK AAWIPHVEN 
RQMAYENLN DKDQELGEY LARMLVKYP 
EIINSNQVK RVPGQGSSE DDLQEEEQI 
EQAIKEHLN QGSSQETDK LAPVSKRFP 
VGPPKNDDT PNRQYWDED LLMKVLEYL 
NQEKAEKGR EHIAKRAME NM

      Links to other resources

      UniProt P13521
      Ensembl ENST00000305409
      KEGG hsa:7857

      • Anatomical structure: basophil_gonadotroph_cell_of_anterior_pituitary_FSH

        Influenced by:

        • gonadotropin-releasing hormone receptor
          in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
          • Co-localization and co-release of LH and SgII in vivo. [3]
          • Close correlation between GnRH-stimulated release of both LH and SgII in vitro. [4]

      Targets

      Cell
      No records found.
      Reference