Please wait ...

Details for messenger / hormone: perlecan

EndoNet ID: ENH00795

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like
If the search pattern is unambigious the user is directed to the corresponding detail page.


  • perlecan
  • HSPG2
  • heparan sulfate proteoglycan 2
  • endorepellin
  • SJS1
  • basement membrane-specific heparan sulfate proteoglycan core protein
  • PLC

General information

  • Perlecan binds FGF-2, which is critical in vascular development and wound healing. [1]
  • Perlecan binds dimers of the chemokine Il-8. [1]
  • Perlecan is also able to bind the growth factor granulocyte/macrophage-colony-stimulating factor. [1]
  • Perlecan is a potent inducer of cell growth and angiogenesis, and therapeutic interventions targeting this key modulator of tumor progression may improve wound healing, including osseous regeneration. [1]
  • Potent inducer of FGF-2-mediated neovascularization. [1]
  • Important component of all basement membranes, it is also thought to play a role in wound healing and angiogenesis. [1]
  • The heparan-sulfate-decorated extracellular biomolecule perlecan is a proteoglycan. [1]
  • Perlecan is thought to modulate binding between the basement membrane structure and various cells, including smooth-muscle cells and aortic endothelial cells. [1]


Hormone function

  • homeostasis
    • cardiovascular control
    • immune response
      • activation

      Chemical classification

      Links to other resources

      UniProt P98160
      Ensembl ENST00000374695
      KEGG hsa:3339


        Celldystroglycanintegrin alpha-3/beta-1
        keratinocyte Present
        smooth muscle cell Present
        • smooth muscle cell migration