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Details for messenger / hormone: free fatty acid

EndoNet ID: ENH00807

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Synonyms

  • FFA
  • free fatty acid

General information

  • Free fatty acid overload attenuates Ca2+ signaling and NO production in endothelial cells. [1]
  • Elevated serum free fatty acid concentrations inhibit T lymphocyte signaling. [2]

Classification

Hormone function

  • immune response
    • inhibition
    • metabolism
      • nutrient supply

      Chemical classification

      Links to other resources

      • Anatomical structure: adipose_tissue

      • Anatomical structure: fat_cell

      Targets

      Cellfree fatty acid receptor 1PPAR beta/deltaPPARgamma1
      adipose tissue Present
      Present
      Phenotypes
      • regulation of fat cell differentiation
      • negative regulation of transcription
      • regulation of glucose homeostasis
      Influences
      • haptoglobin
      • resistin
      • adiponectin
      • leptin
      B-lymphocyte Present
      beta cell of islet of Langerhans Present
      Influences
      • insulin
      • insulin
      bone marrow Present
      brain Present
      Present
      breast Present
      colon Present
      heart Present
      Phenotypes
      • regulation of glucose homeostasis
      immune system Present
      kidney Present
      Present
      large intestine Present
      Present
      lipocyte of liver Present
      Phenotypes
      • involvement in liver steatosis
      liver Present
      lung Present
      macrophage Present
      microglial cell in central nervous system Present
      monocyte Present
      Influences
      • FABP4
      • resistin
      ovary Present
      placenta Present
      Present
      retina Present
      skeleton muscle Present
      Present
      Phenotypes
      • regulation of glucose and lipid metabolism
      • regulation of glucose metabolic process
      skin Present
      small intestine Present
      Present
      smooth muscle Present
      smooth muscle cell Present
      spleen Present
      T-lymphocyte Present
      testis Present
      vascularendothelial cell Present
      Reference