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Details for messenger / hormone: laminin-10

EndoNet ID: ENH00823

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Synonyms

  • laminin-10
  • laminin 10
  • laminin alpha-5/beta-1/gamma-1

General information

  • MAPK are involved in laminin signaling. [1]
  • Elongated alpha5-chain short arm, larger than original full-sized laminins. [2]
  • Laminin is essential for basement membrane assembly, promotes cell attachment and angiogenesis, induces neurite outgrowth, affects gene expression and is involved in cell proliferation, migration and differentiation. [1]
  • Laminin promotes tumor cell invasion by induction of proteases that degrade various components of the extracellular matrix. [1]

Classification

Hormone function

  • development and growth
    • growth stimulation
    • immune response
      • activation
      • metabolism
        • cell metabolism

        Chemical classification

        Composition

        subunit alpha-5

        Sequence
        REEAGGGFS LHPPYFNLA EGARIAASA 
        TCGEEAPAR GSPRPTEDL YCKLVGGPV 
        AGGDPNQTI RGQYCDICT AANSNKAHP 
        ASNAIDGTE RWWQSPPLS RGLEYNEVN 
        VTLDLGQVF HVAYVLIKF ANSPRPDLW 
        VLERSMDFG RTYQPWQFF ASSKRDCLE 
        RFGPQTLER ITRDDAAIC TTEYSRIVP 
        LENGEIVVS LVNGRPGAM NFSYSPLLR 
        EFTKATNVR LRFLRTNTL LGHLMGKAL 
        RDPTVTRRY YYSIKDISI GGRCVCHGH 
        ADACDAKDP TDPFRLQCT CQHNTCGGT 
        CDRCCPGFN QQPWKPATA NSANECQSC 
        NCYGHATDC YYDPEVDRR RASQSLDGT 
        YQGGGVCID CQHHTTGVN CERCLPGFY 
        RSPNHPLDS PHVCRRCNC ESDFTDGTC 
        EDLTGRCYC RPNFSGERC DVCAEGFTG 
        FPSCYPTPS SSNDTREQV LPAGQIVNC 
        DCSAAGTQG NACRKDPRV GRCLCKPNF 
        QGTHCELCA PGFYGPGCQ PCQCSSPGV 
        ADDRCDPDT GQCRCRVGF EGATCDRCA 
        PGYFHFPLC QLCGCSPAG TLPEGCDEA 
        GRCLCQPEF AGPHCDRCR PGYHGFPNC 
        QACTCDPRG ALDQLCGAG GLCRCRPGY 
        TGTACQECS PGFHGFPSC VPCHCSAEG 
        SLHAACDPR SGQCSCRPR VTGLRCDTC 
        VPGAYNFPY CEAGSCHPA GLAPVDPAL 
        PEAQVPCMC RAHVEGPSC DRCKPGFWG 
        LSPSNPEGC TRCSCDLRG TLGGVAECQ 
        PGTGQCFCK PHVCGQACA SCKDGFFGL 
        DQADYFGCR SCRCDIGGA LGQSCEPRT 
        GVCRCRPNT QGPTCSEPA RDHYLPDLH 
        HLRLELEEA ATPEGHAVR FGFNPLEFE 
        NFSWRGYAQ MAPVQPRIV ARLNLTSPD 
        LFWLVFRYV NRGAMSVSG RVSVREEGR 
        SATCANCTA QSQPVAFPP STEPAFITV 
        PQRGFGEPF VLNPGTWAL RVEAEGVLL 
        DYVVLLPSA YYEAALLQL RVTEACTYR 
        PSAQQSGDN CLLYTHLPL DGFPSAAGL 
        EALCRQDNS LPRPCPTEQ LSPSHPPLI 
        TCTGSDVDV QLQVAVPQP GRYALVVEY 
        ANEDARQEV GVAVHTPQR APQQGLLSL 
        HPCLYSTLC RGTARDTQD HLAVFHLDS 
        EASVRLTAE QARFFLHGV TLVPIEEFS 
        PEFVEPRVS CISSHGAFG PNSAACLPS 
        RFPKPPQPI ILRDCQVIP LPPGLPLTH 
        AQDLTPAMS PAGPRPRPP TAVDPDAEP 
        TLLREPQAT VVFTTHVPT LGRYAFLLH 
        GYQPAHPTF PVEVLINAG RVWQGHANA 
        SFCPHGYGC RTLVVCEGQ ALLDVTHSE 
        LTVTVRVPK GRWLWLDYV LVVPENVYS 
        FGYLREEPL DKSYDFISH CAAQGYHIS 
        PSSSSLFCR NAAASLSLF YNNGARPCG 
        CHEVGATGP TCEPFGGQC PCHAHVIGR 
        DCSRCATGY WGFPNCRPC DCGARLCDE 
        LTGQCICPP RTIPPDCLL CQPQTFGCH 
        PLVGCEECN CSGPGIQEL TDPTCDTDS 
        GQCKCRPNV TGRRCDTCS PGFHGYPRC 
        RPCDCHEAG TAPGVCDPL TGQCYCKEN 
        VQGPKCDQC SLGTFSLDA ANPKGCTRC 
        FCFGATERC RSSSYTRQE FVDMEGWVL 
        LSTDRQVVP HERQPGTEM LRADLRHVP 
        EAVPEAFPE LYWQAPPSY LGDRVSSYG 
        GTLRYELHS ETQRGDVFV PMESRPDVV 
        LQGNQMSIT FLEPAYPTP GHVHRGQLQ 
        LVEGNFRHT ETRNTVSRE ELMMVLASL 
        EQLQIRALF SQISSAVFL RRVALEVAS 
        PAGQGALAS NVELCLCPA SYRGDSCQE 
        CAPGFYRDV KGLFLGRCV PCQCHGHSD 
        RCLPGSGVC VDCQHNTEG AHCERCQAG 
        FVSSRDDPS APCVSCPCP LSVPSNNFA 
        EGCVLRGGR TQCLCKPGY AGASCERCA 
        PGFFGNPLV LGSSCQPCD CSGNGDPNL 
        LFSDCDPLT GACRGCLRH TTGPRCEIC 
        APGFYGNAL LPGNCTRCD CTPCGTEAC 
        DPHSGHCLC KAGVTGRRC DRCQEGHFG 
        FDGCGGCRP CACGPAAEG SECHPQSGQ 
        CHCRPGTMG PQCRECAPG YWGLPEQGC 
        RRCQCPGGR CDPHTGRCN CPPGLSGER 
        CDTCSQQHQ VPVPGGPVG HSIHCEVCD 
        HCVVLLLDD LERAGALLP AIHEQLRGI 
        NASSMAWAR LHRLNASIA DLQSQLRSP 
        LGPRHETAQ QLEVLEQQS TSLGQDARR 
        LGGQAVGTR DQASQLLAG TEATLGHAK 
        TLLAAIRAV DRTLSELMS QTGHLGLAN 
        ASAPSGEQL LRTLAEVER LLWEMRARD 
        LGAPQAAAE AELAAAQRL LARVQEQLS 
        SLWEENQAL ATQTRDRLA QHEAGLMDL 
        REALNRAVD ATREAQELN SRNQERLEE 
        ALQRKQELS RDNATLQAT LHAARDTLA 
        SVFRLLHSL DQAKEELER LAASLDGAR 
        TPLLQRMQT FSPAGSKLR LVEAAEAHA 
        QQLGQLALN LSSIILDVN QDRLTQRAI 
        EASNAYSRI LQAVQAAED AAGQALQQA 
        DHTWATVVR QGLVDRAQQ LLANSTALE 
        EAMLQEQQR LGLVWAALQ GARTQLRDV 
        RAKKDQLEA HIQAAQAML AMDTDETSK 
        KIAHAKAVA AEAQDTATR VQSQLQAMQ 
        ENVERWQGQ YEGLRGQDL GQAVLDAGH 
        SVSTLEKTL PQLLAKLSI LENRGVHNA 
        SLALSASIG RVRELIAQA RGAASKVKV 
        PMKFNGRSG VQLRTPRDL ADLAAYTAL 
        KFYLQGPEP EPGQGTEDR FVMYMGSRQ 
        ATGDYMGVS LRDKKVHWV YQLGEAGPA 
        VLSIDEDIG EQFAAVSLD RTLQFGHMS 
        VTVERQMIQ ETKGDTVAP GAEGLLNLR 
        PDDFVFYVG GYPSTFTPP PLLRFPGYR 
        GCIEMDTLN EEVVSLYNF ERTFQLDTA 
        VDRPCARSK STGDPWLTD GSYLDGTGF 
        ARISFDSQI STTKRFEQE LRLVSYSGV 
        LFFLKQQSQ FLCLAVQEG SLVLLYDFG 
        AGLKKAVPL QPPPPLTSA SKAIQVFLL 
        GGSRKRVLV RVERATVYS VEQDNDLEL 
        ADAYYLGGV PPDQLPPSL RRLFPTGGS 
        VRGCVKGIK ALGKYVDLK RLNTTGVSA 
        GCTADLLVG RAMTFHGHG FLRLALSNV 
        APLTGNVYS GFGFHSAQD SALLYYRAS 
        PDGLCQVSL QQGRVSLQL LRTEVKTQA 
        GFADGAPHY VAFYSNATG VWLYVDDQL 
        QQMKPHRGP PPELQPQPE GPPRLLLGG 
        LPESGTIYN FSGCISNVF VQRLLGPQR 
        VFDLQQNLG SVNVSTGCA PALQAQTPG 
        LGPRGLQAT ARKASRRSR QPARHPACM 
        LPPHLRTTR DSYQFGGSL SSHLEFVGI 
        LARHRNWPS LSMHVLPRS SRGLLLFTA 
        RLRPGSPSL ALFLSNGHF VAQMEGLGT 
        RLRAQSRQR SRPGRWHKV SVRWEKNRI 
        LLVTDGARA WSQEGPHRQ HQGAEHPQP 
        HTLFVGGLP ASSHSSKLP VTVGFSGCV 
        KRLRLHGRP LGAPTRMAG VTPCILGPL 
        EAGLFFPGS GGVITLDLP GATLPDVGL 
        ELEVRPLAV TGLIFHLGQ ARTPPYLQL 
        QVTEKQVLL RADDGAGEF STSVTRPSV 
        LCDGQWHRL AVMKSGNVL RLEVDAQSN 
        HTVGPLLAA AAGAPAPLY LGGLPEPMA 
        VQPWPPAYC GCMRRLAVN RSPVAMTRS 
        VEVHGAVGA SGCPAA
        UniProt O15230

        subunit beta-1

        Sequence
        QEPEFSYGC AEGSCYPAT GDLLIGRAQ 
        KLSVTSTCG LHKPEPYCI VSHLQEDKK 
        CFICNSQDP YHETLNPDS HLIENVVTT 
        FAPNRLKIW WQSENGVEN VTIQLDLEA 
        EFHFTHLIM TFKTFRPAA MLIERSSDF 
        GKTWGVYRY FAYDCEASF PGISTGPMK 
        KVDDIICDS RYSDIEPST EGEVIFRAL 
        DPAFKIEDP YSPRIQNLL KITNLRIKF 
        VKLHTLGDN LLDSRMEIR EKYYYAVYD 
        MVVRGNCFC YGHASECAP VDGFNEEVE 
        GMVHGHCMC RHNTKGLNC ELCMDFYHD 
        LPWRPAEGR NSNACKKCN CNEHSISCH 
        FDMAVYLAT GNVSGGVCD DCQHNTMGR 
        NCEQCKPFY YQHPERDIR DPNFCERCT 
        CDPAGSQNE GICDSYTDF STGLIAGQC 
        RCKLNVEGE HCDVCKEGF YDLSSEDPF 
        GCKSCACNP LGTIPGGNP CDSETGHCY 
        CKRLVTGQH CDQCLPEHW GLSNDLDGC 
        RPCDCDLGG ALNNSCFAE SGQCSCRPH 
        MIGRQCNEV EPGYYFATL DHYLYEAEE 
        ANLGPGVSI VERQYIQDR IPSWTGAGF 
        VRVPEGAYL EFFIDNIPY SMEYDILIR 
        YEPQLPDHW EKAVITVQR PGRIPTSSR 
        CGNTIPDDD NQVVSLSPG SRYVVLPRP 
        VCFEKGTNY TVRLELPQY TSSDSDVES 
        PYTLIDSLV LMPYCKSLD IFTVGGSGD 
        GVVTNSAWE TFQRYRCLE NSRSVVKTP 
        MTDVCRNII FSISALLHQ TGLACECDP 
        QGSLSSVCD PNGGQCQCR PNVVGRTCN 
        RCAPGTFGF GPSGCKPCE CHLQGSVNA 
        FCNPVTGQC HCFQGVYAR QCDRCLPGH 
        WGFPSCQPC QCNGHADDC DPVTGECLN 
        CQDYTMGHN CERCLAGYY GDPIIGSGD 
        HCRPCPCPD GPDSGRQFA RSCYQDPVT 
        LQLACVCDP GYIGSRCDD CASGYFGNP 
        SEVGGSCQP CQCHNNIDT TDPEACDKE 
        TGRCLKCLY HTEGEHCQF CRFGYYGDA 
        LQQDCRKCV CNYLGTVQE HCNGSDCQC 
        DKATGQCLC LPNVIGQNC DRCAPNTWQ 
        LASGTGCDP CNCNAAHSF GPSCNEFTG 
        QCQCMPGFG GRTCSECQE LFWGDPDVE 
        CRACDCDPR GIETPQCDQ STGQCVCVE 
        GVEGPRCDK CTRGYSGVF PDCTPCHQC 
        FALWDVIIA ELTNRTHRF LEKAKALKI 
        SGVIGPYRE TVDSVERKV SEIKDILAQ 
        SPAAEPLKN IGNLFEEAE KLIKDVTEM 
        MAQVEVKLS DTTSQSNST AKELDSLQT 
        EAESLDNTV KELAEQLEF IKNSDIRGA 
        LDSITKYFQ MSLEAEERV NASTTEPNS 
        TVEQSALMR DRVEDVMME RESQFKEKQ 
        EEQARLLDE LAGKLQSLD LSAAAEMTC 
        GTPPGASCS ETECGGPNC RTDEGERKC 
        GGPGCGGLV TVAHNAWQK AMDLDQDVL 
        SALAEVEQL SKMVSEAKL RADEAKQSA 
        EDILLKTNA TKEKMDKSN EELRNLIKQ 
        IRNFLTQDS ADLDSIEAV ANEVLKMEM 
        PSTPQQLQN LTEDIRERV ESLSQVEVI 
        LQHSAADIA RAEMLLEEA KRASKSATD 
        VKVTADMVK EALEEAEKA QVAAEKAIK 
        QADEDIQGT QNLLTSIES ETAASEETL 
        FNASQRISE LERNVEELK RKAAQNSGE 
        AEYIEKVVY TVKQSAEDV KKTLDGELD 
        EKYKKVENL IAKKTEESA DARRKAEML 
        QNEAKTLLA QANSKLQLL KDLERKYED 
        NQRYLEDKA QELARLEGE VRSLLKDIS 
        QKVAVYSTC L
        UniProt P07942

        subunit gamma-1

        Sequence
        QAAMDECTD EGGRPQRCM PEFVNAAFN 
        VTVVATNTC GTPPEEYCV QTGVTGVTK 
        SCHLCDAGQ PHLQHGAAF LTDYNNQAD 
        TTWWQSQTM LAGVQYPSS INLTLHLGK 
        AFDITYVRL KFHTSRPES FAIYKRTRE 
        DGPWIPYQY YSGSCENTY SKANRGFIR 
        TGGDEQQAL CTDEFSDIS PLTGGNVAF 
        STLEGRPSA YNFDNSPVL QEWVTATDI 
        RVTLNRLNT FGDEVFNDP KVLKSYYYA 
        ISDFAVGGR CKCNGHASE CMKNEFDKL 
        VCNCKHNTY GVDCEKCLP FFNDRPWRR 
        ATAESASEC LPCDCNGRS QECYFDPEL 
        YRSTGHGGH CTNCQDNTD GAHCERCRE 
        NFFRLGNNE ACSSCHCSP VGSLSTQCD 
        SYGRCSCKP GVMGDKCDR CQPGFHSLT 
        EAGCRPCSC DPSGSIDEC NIETGRCVC 
        KDNVEGFNC ERCKPGFFN LESSNPRGC 
        TPCFCFGHS SVCTNAVGY SVYSISSTF 
        QIDEDGWRA EQRDGSEAS LEWSSERQD 
        IAVISDSYF PRYFIAPAK FLGKQVLSY 
        GQNLSFSFR VDRRDTRLS AEDLVLEGA 
        GLRVSVPLI AQGNSYPSE TTVKYVFRL 
        HEATDYPWR PALTPFEFQ KLLNNLTSI 
        KIRGTYSER SAGYLDDVT LASARPGPG 
        VPATWVESC TCPVGYGGQ FCEMCLSGY 
        RRETPNLGP YSPCVLCAC NGHSETCDP 
        ETGVCNCRD NTAGPHCEK CSDGYYGDS 
        TAGTSSDCQ PCPCPGGSS CAVVPKTKE 
        VVCTNCPTG TTGKRCELC DDGYFGDPL 
        GRNGPVRLC RLCQCSDNI DPNAVGNCN 
        RLTGECLKC IYNTAGFYC DRCKDGFFG 
        NPLAPNPAD KCKACNCNL YGTMKQQSS 
        CNPVTGQCE CLPHVTGQD CGACDPGFY 
        NLQSGQGCE RCDCHALGS TNGQCDIRT 
        GQCECQPGI TGQHCERCE VNHFGFGPE 
        GCKPCDCHP EGSLSLQCK DDGRCECRE 
        GFVGNRCDQ CEENYFYNR SWPGCQECP 
        ACYRLVKDK VADHRVKLQ ELESLIANL 
        GTGDEMVTD QAFEDRLKE AEREVMDLL 
        REAQDVKDV DQNLMDRLQ RVNNTLSSQ 
        ISRLQNIRN TIEETGNLA EQARAHVEN 
        TERLIEIAS RELEKAKVA AANVSVTQP 
        ESTGDPNNM TLLAEEARK LAERHKQEA 
        DDIVRVAKT ANDTSTEAY NLLLRTLAG 
        ENQTAFEIE ELNRKYEQA KNISQDLEK 
        QAARVHEEA KRAGDKAVE IYASVAQLS 
        PLDSETLEN EANNIKMEA ENLEQLIDQ 
        KLKDYEDLR EDMRGKELE VKNLLEKGK 
        TEQQTADQL LARADAAKA LAEEAAKKG 
        RDTLQEAND ILNNLKDFD RRVNDNKTA 
        AEEALRKIP AINQTITEA NEKTREAQQ 
        ALGSAAADA TEAKNKAHE AERIASAVQ 
        KNATSTKAE AERTFAEVT DLDNEVNNM 
        LKQLQEAEK ELKRKQDDA DQDMMMAGM 
        ASQAAQEAE INARKAKNS VTSLLSIIN 
        DLLEQLGQL DTVDLNKLN EIEGTLNKA 
        KDEMKVSDL DRKVSDLEN EAKKQEAAI 
        MDYNRDIEE IMKDIRNLE DIRKTLPSG 
        CFNTPSIEK P
        UniProt P11047

        Links to other resources

          Targets

          Cellintegrin alpha-3/beta-1integrin alpha-6/beta-1integrin alpha-6/beta-4integrin alpha-7/beta-1
          keratinocyte Present
          Present
          oligodendrocyte Present
          smooth muscle cell Present
          Phenotypes
          • smooth muscle cell migration
          Reference