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Details for messenger / hormone: fibulin 1A

EndoNet ID: ENH00848

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Synonyms

  • fibulin-1 isoform 2
  • FBLN1 isoform 2
  • Fbln-1 isoform 2
  • Fibulin-1
  • fibulin 1A
  • fibulin-1 isoform A

General information

  • Alternative splicing of Fbln-1 precursor RNA results in the expression of four transcripts which encode overlapping polypeptides, designated A-D, differing only in their carboxy terminal domain. [1]
  • The Fbln-1 glycoprotein can self-associate and bind to ECM proteins including fibronectin, laminin, and nidogen, and to the coagulation protein fibrinogen. [1]
  • Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1. [2]
  • GROalpha is highly expressed in adenocarcinoma of the colon and down-regulates fibulin-1. [3]
  • Progesterone induces the fibulin-1 expression in human endometrial stromal cells. [4]
  • Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function. [5]
  • Serum opacity factor is a streptococcal receptor for the extracellular matrix protein fibulin-1. [6]

Classification

Hormone function

  • homeostasis
    • cardiovascular control

    Chemical classification

    Composition

    fibulin-1 isoform A

    Sequence 
    MERAAPSRR VPLPLLLLG GLALLAAGV 
DADVLLEAC CADGHRMAT HQKDCSLPY 
ATESKECRM VQEQCCHSQ LEELHCATG 
ISLANEQDR CATPHGDNA SLEATFVKR 
CCHCCLLGR AAQAQGQSC EYSLMVGYQ 
CGQVFRACC VKSQETGDL DVGGLQETD 
KIIEVEEEQ EDPYLNDRC RGGGPCKQQ 
CRDTGDEVV CSCFVGYQL LSDGVSCED 
VNECITGSH SCRLGESCI NTVGSFRCQ 
RDSSCGTGY ELTEDNSCK DIDECESGI 
HNCLPDFIC QNTLGSFRC RPKLQCKSG 
FIQDALGNC IDINECLSI SAPCPIGHT 
CINTEGSYT CQKNVPNCG RGYHLNEEG 
TRCVDVDEC APPAEPCGK GHRCVNSPG 
SFRCECKTG YYFDGISRM CVDVNECQR 
YPGRLCGHK CENTLGSYL CSCSVGFRL 
SVDGRSCED INECSSSPC SQECANVYG 
SYQCYCRRG YQLSDVDGV TCEDIDECA 
LPTGGHICS YRCINIPGS FQCSCPSSG 
YRLAPNGRN CQDIDECVT GIHNCSINE 
TCFNIQGGF RCLAFECPE NYRRSAAT
    UniProt P23142-2

    Links to other resources

    UniProt P23142-2
    Ensembl ENST00000327858
    KEGG hsa:2192

    • Anatomical structure: placenta

    Targets

    Cell
    No records found.
    Reference