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Details for messenger / hormone: ADNF

EndoNet ID: ENH00875

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  • ADNF
  • activity-dependent neurotrophic factor

General information

  • Femtomolar concentrations of ADNF and a short peptide sequence derived from it (a peptidergic active site) protected neurons from death associated with a broad range of toxins, including those related to Alzheimer's disease, the human immunodeficiency virus, excito-toxicity, and electrical blockade. [1]
  • ADNF and ADNP, as well as their shortened derivatives ADNF-9 and NAP, prevent neurons from electrical blockade, excitotoxicity, apoE deficiency, glucose deficit, ischemia, toxic action of ethanol, beta-amyloid, and gp120. [2]
  • Activity-dependent neurotrophic factor is a factor secreted by glial cells under the action of VIP. [3]


Hormone function

  • immune response
    • activation

    Chemical classification

    Links to other resources

    • Anatomical structure: astroglia

    • Anatomical structure: glial_cell_of_central_nervous_system

    • Anatomical structure: astrocyte


    No records found.