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Details for messenger / hormone: soluble ectodomain of desmoglein-2

EndoNet ID: ENH00936

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  • soluble desmoglein 2
  • cadherin family member 5
  • Desmoglein-2
  • soluble ectodomain of desmoglein-2
  • HDGC
  • DSG2
  • sDSG-2

General information

  • Shedding of the ectodomain of desmoglein-2 is promoted by ADAM10 and ADAM17. [1]
  • Function: required for maintenance of tight junction integrity of intestinal epithel. [2]


Hormone function

  • homeostasis
    • ion flow control

    Chemical classification

    Links to other resources

    UniProt Q14126
    Ensembl ENST00000261590
    KEGG hsa:1829


      astrocyte Present
      brain Present
      cerebellar cortex Present
      cerebral cortex Present
      continuous vascular endothelial cell of blood vessels and lymphatics Present
      • regulation of angiogenesis
      hippocampus Present
      keratinocyte Present
      lung Present
      macrophage Present
      monocyte Present
      • ectodomain shedding
      neuron Present
      neutrophil granulocyte Present
      • ectodomain shedding
      T-lymphocyte Present
      • ectodomain shedding
      uterus Present