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Details for messenger / hormone: proteinase 3

EndoNet ID: ENH00937

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Synonyms

  • PRTN3
  • AGP7
  • ACPA
  • PR-3
  • C-ANCA
  • MBN
  • MBT
  • myeloblastin
  • Wegener granulomatosis autoantigen
  • serine proteinase
  • leukocyte proteinase 3
  • neutrophil proteinase 4
  • NP-4
  • P29
  • Wegener's autoantigen
  • PR3
  • proteinase 3
  • C-ANCA antigen
  • Wegener autoantigen

General information

  • Proteinase 3 is an IL-32 binding protein. [1]
  • PR3, a neutrophil granule serine protease, exists in a soluble or membrane form and is the major autoantigen for autoantibodies in the systemic vasculitic disease, Wegener's granulomatosis. [1]
  • Degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). [2]
  • The secreted proform of neutrophil proteinase 3 regulates the proliferation of granulopoietic progenitor cells. [3]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    Composition

    myeloblastin

    Sequence 
    IVGGHEAQP HSRPYMASL QMRGNPGSH 
FCGGTLIHP SFVLTAAHC LRDIPQRLV 
NVVLGAHNV RTQEPTQQH FSVAQVFLN 
NYDAENKLN DVLLIQLSS PANLSASVA 
TVQLPQQDQ PVPHGTQCL AMGWGRVGA 
HDPPAQVLQ ELNVTVVTF FCRPHNICT 
FVPRRKAGI CFGDSGGPL ICDGIIQGI 
DSFVIWGCA TRLFPDFFT RVALYVDWI 
RSTLR
    UniProt P24158

    Links to other resources

    UniProt P24158
    Ensembl ENST00000234347
    KEGG hsa:5657

    • Anatomical structure: bone_marrow

    • Anatomical structure: glomerulus

    • Anatomical structure: neutrophil_granulocyte

    • Anatomical structure: monocyte

    • Anatomical structure: neutrophil_granulocyte

    Targets

    Cell
    No records found.
    Reference