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Details for messenger / hormone: pregnancy-associated plasma protein A

EndoNet ID: ENH00958

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Synonyms

  • pappalysin-1
  • pregnancy-associated plasma protein-A
  • PAPP-A
  • insulin-like growth factor-dependent IGF-binding protein 4 protease
  • IGF-dependent IGFBP-4 protease
  • IGFBP-4ase
  • PAPPA
  • ASBABP2
  • DIPLA1
  • PAPPA1
  • aspecific BCL-2 ARE-binding protein 2
  • differentially placenta 1 expressed protein
  • pregnancy-associated plasma protein A

General information

  • Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. [1]
  • Function: Control of growth and development by regulating bioavailability of insulin-like growth factor. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    Composition

    pregnancy-associated plasma protein A

    Sequence
    EARGATEEP SPPSRALYF SGRGEQLRL 
    RADLELPRD AFTLQVWLR AEGGQRSPA 
    VITGLYDKC SYISRDRGW VVGIHTISD 
    QDNKDPRYF FSLKTDRAR QVTTINAHR 
    SYLPGQWVY LAATYDGQF MKLYVNGAQ 
    VATSGEQVG GIFSPLTQK CKVLMLGGS 
    ALNHNYRGY IEHFSLWKV ARTQREILS 
    DMETHGAHT ALPQLLLQE NWDNVKHAW 
    SPMKDGSSP KVEFSNAHG FLLDTSLEP 
    PLCGQTLCD NTEVIASYN QLSSFRQPK 
    VVRYRVVNL YEDDHKNPT VTREQVDFQ 
    HHQLAEAFK QYNISWELD VLEVSNSSL 
    RRRLILANC DISKIGDEN CDPECNHTL 
    TGHDGGDCR HLRHPAFVK KQHNGVCDM 
    DCNYERFNF DGGECCDPE ITNVTQTCF 
    DPDSPHRAY LDVNELKNI LKLDGSTHL 
    NIFFAKSSE EELAGVATW PWDKEALMH 
    LGGIVLNPS FYGMPGHTH TMIHEIGHS 
    LGLYHVFRG ISEIQSCSD PCMETEPSF 
    ETGDLCNDT NPAPKHKSC GDPGPGNDT 
    CGFHSFFNT PYNNFMSYA DDDCTDSFT 
    PNQVARMHC YLDLVYQGW QPSRKPAPV 
    ALAPQVLGH TTDSVTLEW FPPIDGHFF 
    ERELGSACH LCLEGRILV QYASNASSP 
    MPCSPSGHW SPREAEGHP DVEQPCKSS 
    VRTWSPNSA VNPHTVPPA CPEPQGCYL 
    ELEFLYPLV PESLTIWVT FVSTDWDSS 
    GAVNDIKLL AVSGKNISL GPQNVFCDV 
    PLTIRLWDV GEEVYGIQI YTLDEHLEI 
    DAAMLTSTA DTPLCLQCK PLKYKVVRD 
    PPLQMDVAS ILHLNRKFV DMDLNLGSV 
    YQYWVITIS GTEESEPSP AVTYIHGSG 
    YCGDGIIQK DQGEQCDDM NKINGDGCS 
    LFCRQEVSF NCIDEPSRC YFHDGDGVC 
    EEFEQKTSI KDCGVYTPQ GFLDQWASN 
    ASVSHQDQQ CPGWVIIGQ PAASQVCRT 
    KVIDLSEGI SQHAWYPCT ISYPYSQLA 
    QTTFWLRAY FSQPMVAAA VIVHLVTDG 
    TYYGDQKQE TISVQLLDT KDQSHDLGL 
    HVLSCRNNP LIIPVVHDL SQPFYHSQA 
    VRVSFSSPL VAISGVALR SFDNFDPVT 
    LSSCQRGET YSPAEQSCV HFACEKTDC 
    PELAVENAS LNCSSSDRY HGAQCTVSC 
    RTGYVLQIR RDDELIKSQ TGPSVTVTC 
    TEGKWNKQV ACEPVDCSI PDHHQVYAA 
    SFSCPEGTT FGSQCSFQC RHPAQLKGN 
    NSLLTCMED GLWSFPEAL CELMCLAPP 
    PVPNADLQT ARCRENKHK VGSFCKYKC 
    KPGYHVPGS SRKSKKRAF KTQCTQDGS 
    WQEGACVPV TCDPPPPKF HGLYQCTNG 
    FQFNSECRI KCEDSDASQ GLGSNVIHC 
    RKDGTWNGS FHVCQEMQG QCSVPNELN 
    SNLKLQCPD GYAIGSECA TSCLDHNSE 
    SIILPMNVT VRDIPHWLN PTRVERVVC 
    TAGLKWYPH PALIHCVKG CEPFMGDNY 
    CDAINNRAF CNYDGGDCC TSTVKTKKV 
    TPFPMSCDL QGDCACRDP QAQEHSRKD 
    LRGYSHG

    Links to other resources

    UniProt Q13219
    Ensembl ENST00000328252
    KEGG hsa:5069
    • Anatomical structure: placenta

    • Anatomical structure: fibroblast

    • Anatomical structure: serum

    Targets

    Cell
    No records found.
    Reference