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Details for messenger / hormone: MMP-7

EndoNet ID: ENH00960

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Synonyms

  • MMP-7
  • matrix metalloproteinase 7
  • MMP7
  • MPSL1
  • PUMP-1
  • matrilysin
  • uterine metalloproteinase
  • matrin
  • matrix metalloproteinase-7
  • pump-1 protease

General information

  • MMP-7 is implicated in various normal processes of tissue remodeling, such as embryonic development, wound healing, trophoblast implantation, and organ morphogenesis. [1]
  • Matrix metalloproteinase-7 is a 19-kDa matrilysin, whose gene maps to human chromosome 11q21-q22. Active MMP-7 has a broad proteolytic activity against several kinds of extracellular matrix substrates, like collagens, fibronectin, laminin, casein, elastin, entactin, cartilage proteoglycan, etc. [1]
  • The proteolytic degradation of MMP-7 contributes to the invasion and metastasis of tumor cells by the following mechanisms: (i) activating other MMP; (ii) increasing angiogenesis; (iii) regulating the mobility of cells; (iv) hydrolyzing the extracellular matrix; (v) influencing the apoptosis of cells. [1]

Classification

Hormone function

  • development and growth
    • embryogenesis
      • environment adaptation

      Chemical classification

      Links to other resources

      UniProt P09237
      Ensembl ENST00000260227
      KEGG hsa:4316

      • Anatomical structure: macrophage

      Targets

      Cell
      No records found.
      Reference