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Details for messenger / hormone: SLPI

EndoNet ID: ENH00962

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Synonyms

  • SLPI
  • secretory leukocyte protease inhibitor
  • antileukoproteinase
  • ALP
  • HUSI-1
  • seminal proteinase inhibitor
  • BLPI
  • mucus proteinase inhibitor
  • MPI
  • WAP four-disulfide core domain protein 4
  • protease inhibitor WAP4
  • WFDC4

General information

  • Acid-stable secreted proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. [1]
  • Contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. [2]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    Composition

    Sequence 
    MKSSGLFPF LVLLALGTL APWAVEGSG 
KSFKAGVCP PKKSAQCLR YKKPECQSD 
WQCPGKKRC CPDTCGIKC LDPVDTPNP 
TRRKPGKCP VTYGQCLML NPPNFCEMD 
GQCKRDLKC CMGMCGKSC VSPVKA

    Links to other resources

    UniProt P03973
    Ensembl ENST00000338380
    KEGG hsa:6590

    • Anatomical structure: epithelial_cell_with_microvilli

      • Expression of the SLPI gene has been extensively examined in superficial epithelial cells from human airways, but SLPI secretion from the superficial epithelium has not yet been clarified [3]
      • SLPI is predominantly in the serous cells of tracheal and bronchial submucosal glands [3]

    Targets

    Cellputative SLPI receptor
    No records found.
    Reference