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Details for messenger / hormone: anandamide (20:4, n-6)

EndoNet ID: ENH01052

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Synonyms

  • anandamide (20:4, n-6)
  • N-Arachidonoylethanolamine
  • N-(5Z,8Z,11Z,14Z-icosatetraenoyl)-ethanolamide
  • AEA

General information

  • anandamide is thought to be hydrolysed to arachidonic acid and ethanolamine by the microsomal enzyme, fatty acid amide hydrolase (FAAH [1]
  • Function: CNS function like mood, motor activity involvement. [2]

Classification

Hormone function

  • CNS function
    • mood / behaviour
      • motor activity

      Chemical classification

      • hormone
        • not genome-encoded
          • eicosanoids/fatty acid derivatives
            • prostanoids

      Composition

      Links to other resources

      KEGG C11695
      LIPID MAPS LMFA08040001
      LipidBank XPR7001

      • Anatomical structure: neuron

        • Neuronal synthesis and release of anandamide and 2- arachidonoyl glycerol is also calcium-dependent. [1]
        • AEA is an ethanolamide derivative of AA. Arachidonic acid is derived from membrane lipids by selective activation of Ca2+-dependent PLA2, which releases the Sn-2- arachidonyl moiety from the membrane PL, phosphatidylcholine (PC). [3]

      Targets

      CellCB1CB2
      adrenal gland Present
      Influences
      • ↓ CGRP1
      • ↓ acetylcholine
      • ↓ cholecystokinin
      basket cell Present
      Influences
      • ↓ GABA
      cerebellum Present
      Influences
      • ↓ GABA
      • ↓ glutamate
      cerebral cortex Present
      Influences
      • ↓ serotonin
      heart Present
      Phenotypes
      • atrial muscle contraction
      hippocampus Present
      Influences
      • ↓ GABA
      leukocyte Present
      lung Present
      pallidum Present
      peripheral nerve system element Present
      reticular part of substantia nigra Present
      Influences
      • ↓ GABA
      spinal cord Present
      urinary bladder Present
      Phenotypes
      • urination
      Reference