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Details for messenger / hormone: lysophosphatidylcholine

EndoNet ID: ENH01132

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Synonyms

  • lysophosphatidylcholine
  • LPC
  • lysolecithine

General information

  • LPCs result from partial hydrolysis of phosphatidylcholines which removes one of the fatty acid groups. The hydroylsis is generally the result of the enzymatic action of phospholipase A2.
  • LPC is present as a component of oxidized low-density lipoprotein (LDL). [1]
  • It can be produced from phosphatidylcholine by phospholipase A2. [1]
  • LPC can exist in several physiological forms, including free, micellar, LDL, bound to hydrophobic serum proteins such as albumin, consumed within immune complexes, and incorporated into plasma membranes. [2]

Classification

Hormone function

  • metabolism
    • cell metabolism

    Chemical classification

    Links to other resources

      Targets

      CellG-protein coupled receptor 4Probable G-protein coupled receptor 132
      bone marrow Present
      brain Present
      continuous vascular endothelial cell of blood vessels and lymphatics Present
      Phenotypes
      • positive regulation of cell growth
      dendritic cell in lymphoid tissues Present
      Phenotypes
      • regulation of innate immune response
      heart Present
      		Present
      immune system Present
      keratinocyte Present
      Phenotypes
      • positive regulation of cell growth
      kidney Present
      liver Present
      lung Present
      		Present
      lymph node Present
      		Present
      Phenotypes
      • lymphocyte homeostasis
      lymphocyte Present
      Phenotypes
      • regulation of actin cytoskeleton organization
      • lymphocyte homeostasis
      macrophage Present
      Phenotypes
      • atherosclerosis
      		Present
      Phenotypes
      • regulation of innate immune response
      • atherosclerosis
      ovary Present
      smooth muscle cell Present
      Phenotypes
      • positive regulation of cell growth
      spleen Present
      Phenotypes
      • lymphocyte homeostasis
      T-lymphocyte Present
      Phenotypes
      • Systemic lupus erythematosus
      • modulation of T cell response
      • regulation of T cell activation
      thymus Present
      Reference