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Statistic
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Details for phenotype: neonatal hyperparathyroidism
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EndoNet ID: ENP00071
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Name
neonatal hyperparathyroidism
General information
This phenotype is not pathologic
Links to other resources
GO
regulation of hormone secretion
Medline Plus
001215
Disease database
20710
Phenotype triggers
no activity (knock out experiment or RNAi) of
CaSR
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in
thyroid_gland
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Extracellular calcium ions are recognized as principal physiological regulators of parathyroid hormone secretion acting to close a endocrine feedback loop, whereby parathyroid hormone elevates extracellular calcium and in turn elevated extracellular calium suppresses parathyroid hormone secretion.
[1]
Targeted deletion of CaSR eliminates feedback control of parathyroid hormone secretion and results in severe form of neonatal hyperparathyroidism.
[1]
Reference
