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Details for phenotype: steroidogenesis

EndoNet ID: ENP00087

Name

steroidogenesis

General information

This phenotype is not pathologic

Links to other resources

GO

Phenotype triggers

  • normal activity of angiotensin II type 1 receptor
    in ovary
    • Angiotensin II has many roles in the ovary, including steroidogenesis. [1]
  • normal activity of steroidogenic factor 1
    in gonads
    • SF-1 is a master regulator of steroidogenesis whose expression is critical for normal adrenal and gonadal organogenesis. Strict maintenance of SF-1 levels is essential, and mutations causing under- or overexpression result in congenital adrenal and gonadal defects or hyperplasia, respectively [2]
  • normal activity of ER-beta
    in Leydig_cell_of_testis
    • Estrogen regulates steroidogenesis by acting through ER alpha and ER beta in the Leydig cells. [3]
  • normal activity of ER-alpha
    in Leydig_cell_of_testis
    • Estrogen regulates steroidogenesis by acting through ER alpha and ER beta in the Leydig cells. [3]
Reference