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Statistic
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Details for phenotype: positive regulation of apoptosis
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EndoNet ID: ENP00102
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Name
positive regulation of apoptosis
General information
This phenotype is not pathologic
Links to other resources
GO
positive regulation of apoptosis
MeSH term
68017209
Phenotype triggers
normal activity of
TNFR1
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in
hepatocyte
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TNF-induced autocrine TGF- and IL-1alpha/beta contribute to multiple intracellular signaling pathways that govern hepatocyte apoptosis.
[1]
Autocrine IL-1alpha/beta regulates proapoptotic signaling through JNK and p38 pathways.
[1]
normal activity of
TNFR2
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in
hepatocyte
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TNF-induced autocrine TGF- and IL-1alpha/beta contribute to multiple intracellular signaling pathways that govern hepatocyte apoptosis.
[1]
Autocrine IL-1alpha/beta regulates proapoptotic signaling through JNK and p38 pathways.
[1]
more activity (high ligand concentration, overexpression) of
neuropilin 1
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in
glomerulus
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Sema3a overexpression in podocytes during organogenesis leads to glomerular hypoplasia and glomerular endothelial apoptosis.
[2]
normal activity of
TNFRSF25
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in
prostate
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TNFRSF25 is weakly expressed in the prostate. One biological role of TNFRSF25 may be to trigger a cell-death program upon binding of its cognate ligand.
[3]
In addition, TNFRSF25 appears to be capable of activating the transcription factor NF-κB, suggesting that, like TNFR1, this receptor may regulate distinct signaling pathways in different cellular contexts.
[3]
Reference