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Details for phenotype: positive regulation of apoptosis

EndoNet ID: ENP00102

Name

positive regulation of apoptosis

General information

This phenotype is not pathologic

Links to other resources

GO
MeSH term 68017209

Phenotype triggers

  • normal activity of TNFR1
    in hepatocyte
    • TNF-induced autocrine TGF- and IL-1alpha/beta contribute to multiple intracellular signaling pathways that govern hepatocyte apoptosis. [1]
    • Autocrine IL-1alpha/beta regulates proapoptotic signaling through JNK and p38 pathways. [1]
  • normal activity of TNFR2
    in hepatocyte
    • TNF-induced autocrine TGF- and IL-1alpha/beta contribute to multiple intracellular signaling pathways that govern hepatocyte apoptosis. [1]
    • Autocrine IL-1alpha/beta regulates proapoptotic signaling through JNK and p38 pathways. [1]
  • more activity (high ligand concentration, overexpression) of neuropilin 1
    in glomerulus
    • Sema3a overexpression in podocytes during organogenesis leads to glomerular hypoplasia and glomerular endothelial apoptosis. [2]
  • normal activity of TNFRSF25
    in prostate
    • TNFRSF25 is weakly expressed in the prostate. One biological role of TNFRSF25 may be to trigger a cell-death program upon binding of its cognate ligand. [3]
    • In addition, TNFRSF25 appears to be capable of activating the transcription factor NF-κB, suggesting that, like TNFR1, this receptor may regulate distinct signaling pathways in different cellular contexts. [3]
Reference