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Details for phenotype: axon guidance

EndoNet ID: ENP00106

Name

axon guidance

General information

This phenotype is not pathologic

Links to other resources

GO
MeSH term 68002465

Phenotype triggers

  • normal activity of PLXNB1
    in brain
    • Binding of CD100/Sema4D to plexin-B1 (plexin-B1 associates with active Rac) leads to subsequent RhoA activation, this is responsible for CD100/Sema4D-induced growth cone collapse and neurite retraction, demonstrating a requirement for Rho guanine nuclear exchange factors (RhoGEFs) and RhoA activation in CD100/Sema4D-mediated cytoskeletal changes. [1]
  • normal activity of PLXNB1
    in hippocampus
    • CD100/Sema4D induced growth cone collapse in hippocampal neurons. [2]
    • CD100/Sema4D-Plexin-B1 interactions help to guide developing neuronal cells. [3]
  • normal activity of neuropilin 1
    in brain
    • Semaphorin 3a is a chemorepellent with multiple guidance functions, including axon pathfinding. [4]
  • normal activity of neuropilin-2
    in neuron
    • nitially found expressed in neuronal and then later in endothelial cells, it is well established that the transmembrane glycoproteins neuropilin-1 (NRP1) and neuropilin-2 (NRP2) play essential roles in axonal growth and guidance and in physiological and pathological angiogenesis [5]
Reference