Details for phenotype: B cell response/activation

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EndoNet ID: ENP00108

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Name

B cell response/activation

General information

This phenotype is not pathologic

Links to other resources

GO	positive regulation of B cell activation

Phenotype triggers

• no activity (knock out experiment or RNAi) of CD72 ui-button
  in B-lymphocyte ui-button
  • CD100/Sema4D enhances B cell responses by shutting off CD72-mediated negative signalling. [1]
  • CD100/Sema4D-CD72 interaction is a unique example of ligand binding to a negative regulator yielding a positive output. [2]

EndoNet at the Institut for Bioinformatics UMG Göttingen