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Statistic
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Details for phenotype: hyperphagia
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EndoNet ID: ENP00139
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Name
hyperphagia
General information
This phenotype is not pathologic
Links to other resources
Medline Plus
001214
Disease database
29453
Phenotype triggers
CRF-R1
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in
paraventricular_nucleus_of_hypothalamus
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Systemic deficit in insulin and corticosterone results in opposite effects on the central expression of CRF and CRF-R1. Uncontrolled diabetes led to a decrease in CRF expression in parvocellular PVN. Insulin and corticosterone deficiency have the opposite effects on the hypophysiotropic CRF and CRF-R1. Alterations in the brain CRF system due to insulin deficiency may contribute to the hyperphagia in diabetes.
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Reference
