Details for phenotype: hyperactivity of HPA axis

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EndoNet ID: ENP00142

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Name

hyperactivity of HPA axis

General information

This phenotype is not pathologic

Links to other resources

Phenotype triggers

• CRF-R2 ui-button
  in ventromedial_nucleus_of_hypothalamus ui-button
  • Levels of the CRF-R2 mRNA in the VMH were significantly lower in diabetic rats. Expression of CRF-R2 is mostly related to the insulin, but not to the corticosterone, status. Alterations in the brain CRF system due to insulin deficiency may contribute to the hyperdipsia in diabetes. [1]
  • Basal HPA axis may also be affected by magnocellular CRF that directly stimulates the AVP secretion through a paracrine mechanism at the level of neurohemal zone of the neurohypophysis. [1]

EndoNet at the Institut for Bioinformatics UMG Göttingen