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Details for phenotype: hyperactvity of HPA axis

EndoNet ID: ENP00143

Name

hyperactvity of HPA axis

General information

This phenotype is not pathologic

Links to other resources

Phenotype triggers

  • CRF-R1
    in paraventricular_nucleus_of_hypothalamus
    • Systemic deficit in insulin and corticosterone results in opposite effects on the central expression of CRF and CRF-R1. Uncontrolled diabetes led to a decrease in CRF expression in parvocellular PVN. Insulin and corticosterone deficiency have the opposite effects on the hypophysiotropic CRF and CRF-R1. Alterations in the brain CRF system due to insulin deficiency may contribute to the hyperactivity of the HPA axis in diabetes. [1]
    • Basal HPA axis may also be affected by magnocellular CRF that directly stimulates the AVP secretion through a paracrine mechanism at the level of neurohemal zone of the neurohypophysis. [1]
Reference