Details for phenotype: insulin resistance

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EndoNet ID: ENP00151

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Name

insulin resistance

General information

This phenotype is not pathologic

Links to other resources

GO	insulin receptor activity
MeSH term	68007333

Phenotype triggers

• more activity (high ligand concentration, overexpression) of leptin receptor ui-button
  in adipose_tissue ui-button
  • The obesity-related increase of Leptin production positively correlated with increased insulin resistance. [1]
  • More direct measures of insulin sensitivity have indicated leptin as potential mediator of insulin resistance in obesity. [2]
• more activity (high ligand concentration, overexpression) of TNFR1 ui-button
  in adipose_tissue ui-button
  • The obesity-related increase in TNF-alpha production positively correlates with increased insulin resistance. [3]
  • More direct measures of insulin sensitivity have indicated TNF alpha as potential mediator of insulin resistance in obesity. [3]

EndoNet at the Institut for Bioinformatics UMG Göttingen