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Statistic
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Details for phenotype: regulation of synapse organization
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EndoNet ID: ENP00174
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Name
regulation of synapse organization
General information
This phenotype is not pathologic
Links to other resources
GO
regulation of synapse organization
regulation of synapse structure and activity
MeSH term
68013569
Phenotype triggers
normal activity of
ER-beta
ui-button
in
arcuate_nucleus_of_hypothalamus
ui-button
Estrogen has a facilitatory effect on the formation of new spine synapses in the arcuate neurons, reflecting a circuit remodeling in the ARC after estrogen treatment.
[1]
17ß-estradiol administration lead to changes in the neuronal membrane ultrastructure within the ARC.
[2]
normal activity of
leptin receptor
ui-button
in
arcuate_nucleus_of_hypothalamus
ui-button
Leptin induces a fast rewiring of POMC and Npy/Agrp cells in the ARC - peripheral leptin treatment rapidly restored the synaptic inputs in these groups of cells.
[3]
normal activity of
ER-alpha
ui-button
in
arcuate_nucleus_of_hypothalamus
ui-button
Estrogen has a facilitatory effect on the formation of new spine synapses in the arcuate neurons, reflecting a circuit remodeling in the ARC after estrogen treatment.
[1]
17ß-estradiol administration lead to changes in the neuronal membrane ultrastructure within the ARC.
[2]
normal activity of
GHSR
ui-button
in
arcuate_nucleus_of_hypothalamus
ui-button
The orexigenic hormone ghrelin has an inhibitory effect on the synaptic arrangement/rewiring of the POMC and Npy/Agrp cells in the ARC.
[4]
Reference