Status
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Details for phenotype: regulation of synapse organization

EndoNet ID: ENP00174

Name

regulation of synapse organization

General information

This phenotype is not pathologic

Links to other resources

GO
MeSH term 68013569

Phenotype triggers

  • normal activity of ER-beta
    in arcuate_nucleus_of_hypothalamus
    • Estrogen has a facilitatory effect on the formation of new spine synapses in the arcuate neurons, reflecting a circuit remodeling in the ARC after estrogen treatment. [1]
    • 17ß-estradiol administration lead to changes in the neuronal membrane ultrastructure within the ARC. [2]
  • normal activity of leptin receptor
    in arcuate_nucleus_of_hypothalamus
    • Leptin induces a fast rewiring of POMC and Npy/Agrp cells in the ARC - peripheral leptin treatment rapidly restored the synaptic inputs in these groups of cells. [3]
  • normal activity of ER-alpha
    in arcuate_nucleus_of_hypothalamus
    • Estrogen has a facilitatory effect on the formation of new spine synapses in the arcuate neurons, reflecting a circuit remodeling in the ARC after estrogen treatment. [1]
    • 17ß-estradiol administration lead to changes in the neuronal membrane ultrastructure within the ARC. [2]
  • normal activity of GHSR
    in arcuate_nucleus_of_hypothalamus
    • The orexigenic hormone ghrelin has an inhibitory effect on the synaptic arrangement/rewiring of the POMC and Npy/Agrp cells in the ARC. [4]
Reference