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Statistic
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Details for phenotype: regulation of cellular calcium homeostasis
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EndoNet ID: ENP00239
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Name
regulation of cellular calcium homeostasis
General information
This phenotype is not pathologic
Links to other resources
GO
cellular calcium ion homeostasis
Phenotype triggers
normal activity of
Sphingosine 1-phosphate receptor 2
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in
thyroid_gland
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Calcium entry is one of the main regulators of intracellular signaling. Calcium entry pathway is blocked by sphingosine, and activation of sphingosine kinase 1 (SK1) and the production of sphingosine 1-phosphate (S1P), through an autocrine mechanism, facilitate calcium entry through activation of S1P receptor 2. This is a novel mechanism by which the sphingosine-S1P rheostat regulates cellular calcium homeostasis.
[1]
normal activity of
ER-alpha
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in
eccrine_sweat_glands
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The treatment of human eccrine sweat gland cell line NCL-SG3 with estrogen receptor antagonist suggests a role for the estrogen receptor in the release of intracellular calcium from ryanodine-receptor-gated stores. 17beta-estradiol rapidly activates an PKC isoform, PKA and Erk1/2 MAPK in a PKC-delta and estrogen-receptor-dependent manner.
[2]
normal activity of
ER-beta
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in
eccrine_sweat_glands
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17-beta-estradiol rapidly modulates intracellular calcium release from ryanodine-receptor-gated intracellular Calium stores. The signal transduction pathway involves the estrogen receptor coupled to PKC-PKA-Erk1/2 signaling pathway.
[2]
Reference
