Status
Please wait ...

Details for phenotype: cell maturation

EndoNet ID: ENP00262

Name

cell maturation

General information

This phenotype is not pathologic

Links to other resources

GO
MeSH term 68055648

Phenotype triggers

  • normal activity of Lysophosphatidic acid receptor 1
    in oligodendrocyte
    • A significant role for LPA signaling in myelination was suggested by the Lpar1 gene expression pattern that spatially and temporally correlated with oligodendrocyte maturation. [1]
    • Oligodendrocytes, the myelin-forming glial cells in the CNS, express LPA1 and LPA3 during differentiation. [1]
  • normal activity of Lysophosphatidic acid receptor 1
    in vascularendothelial_cell
    • LPA is a mediator in vascular maturation. An initial characterization of knockout mice revealed the presence of frontal cephalic hemorrhages in Lpar1-deficient mice. [2]
  • more activity (high ligand concentration, overexpression) of Sphingosine 1-phosphate receptor 1
    in T-lymphocyte
    • Upregulation of S1PR1 expression or increased S1PR1 signalling suppresses the proliferation and maturation of mouse T cells. [3]
  • normal activity of VPAC2
    in helper_T_cell_Th1
    • In CD4+CD8+thymocytes, PACAP prevents glucocorticoid-induced apoptosis by inhibiting Fas ligand expression, suggesting a possible implication in intrathymic T-cell maturation. [4]
Reference