Details for phenotype: T cell differentiation during immune response

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EndoNet ID: ENP00269

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Name

T cell differentiation during immune response

General information

This phenotype is not pathologic

Links to other resources

GO	T cell differentiation during immune response
MeSH term	68000945

Phenotype triggers

• normal activity of Sphingosine 1-phosphate receptor 1 ui-button
  in T-lymphocyte ui-button
  • S1PR1 might decrease TH1-cell responses in vivo. [1]
  • S1PR1 might increase TH2-cell responses. [1]
  • S1PR1 might polarize TCR-activated cells towards a T helper 17-cell phenotype, thereby altering the immune response. [1]
  • S1P seems to increase the size of the TH17-cell subset through S1PR1 triggering. [2]

EndoNet at the Institut for Bioinformatics UMG Göttingen