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Statistic
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Details for phenotype: schizophrenia
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EndoNet ID: ENP00310
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Name
schizophrenia
General information
This phenotype is pathologic
Links to other resources
GO
sensory processing
OMIM
181500
Medline Plus
000928
MeSH term
F03.700.750
Disease database
11890
Phenotype triggers
no activity (knock out experiment or RNAi) of
Lysophosphatidic acid receptor 1
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in
central_nerve_system_element
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An intriguing link may exist between LPA signaling and neurological diseases such as schizophrenia, on the basis of phenotypic and molecular similarities. Craniofacial dysmorphism, defects in prepulse inhibition, and widespread brain alterations in serotonin neurotransmitter levels are present in both Lpar1-deficient mice and patients suffering from schizophrenia.
[1]
Reference
