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Statistic
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Details for phenotype: positive regulation of glial cell apoptosis
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EndoNet ID: ENP00384
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Name
positive regulation of glial cell apoptosis
General information
This phenotype is not pathologic
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GO
positive regulation of glial cell apoptosis
OMIM
604620
MeSH term
68016923
Phenotype triggers
more activity (high ligand concentration, overexpression) of
Psychosine receptor
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in
oligodendrocyte
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Psy is primarily accumulated in oligodendroglia, which contain abundant GalCer, a precursor of Psy. The accumulated Psy is cytotoxic, and these cells were therefore injured or died on Psy accumulation, probably due to apoptosis.
[1]
Reference
