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Statistic
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Details for phenotype: regulation of blood pressure
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EndoNet ID: ENP00390
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Name
regulation of blood pressure
General information
This phenotype is not pathologic
Links to other resources
GO
regulation of blood pressure
MeSH term
68001794
Phenotype triggers
normal activity of
angiotensin II type 1 receptor
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in
kidney
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Renal AT1 receptors have unique and nonredundant actions in blood pressure homeostasis.
[1]
Blood pressure is regulated by direct effects of AT1 receptors on kidney cells, independent of any impact of mineralocorticoids.
[1]
normal activity of
angiotensin II type 1 receptor
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in
brain
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In the brain, intraventricular injection of angiotensin II causes a dramatic pressor response mediated by AT1 receptors.
[2]
AT1 receptors outside the kidney also make a unique contribution to blood pressure homeostasis that is virtually equivalent to and independent of the intrarenal actions of angiotensin II.
[1]
AT1 receptors in the CNS and/or in the vasculature are more likely to mediate the component of blood pressure regulation that is independent of the kidney.
[1]
Reference
