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Details for phenotype: neuroendocrine cell differentiation

EndoNet ID: ENP00418

Name

neuroendocrine cell differentiation

General information

This phenotype is not pathologic

Links to other resources

GO
MeSH term 68009490

Phenotype triggers

  • normal activity of FTS receptor
    in pituitary_gland_of_diencephalon
    • Recent immunoneutralization studies have strengthened the hypothesis that thymulin is a physiological mediator of the perinatal influence of the thymus on neuroendocrine maturation. Thus, neonatal immunoneutralization of circulating thymulin in otherwise normal C57BL/6 mice induced significant morphologic alterations in most anterior pituitary endocrine cell populations when the animals reached puberty. [1]
    • Thymulin immunoneutralization from birth to puberty in normal mice also induced serum gonadotropin and serum TSH, PRL, and GH reduction when the animals reached puberty. [2]
Reference