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Statistic
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Details for phenotype: neuroendocrine cell differentiation
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EndoNet ID: ENP00418
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Name
neuroendocrine cell differentiation
General information
This phenotype is not pathologic
Links to other resources
GO
neuroendocrine cell differentiation
MeSH term
68009490
Phenotype triggers
normal activity of
FTS receptor
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in
pituitary_gland_of_diencephalon
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Recent immunoneutralization studies have strengthened the hypothesis that thymulin is a physiological mediator of the perinatal influence of the thymus on neuroendocrine maturation. Thus, neonatal immunoneutralization of circulating thymulin in otherwise normal C57BL/6 mice induced significant morphologic alterations in most anterior pituitary endocrine cell populations when the animals reached puberty.
[1]
Thymulin immunoneutralization from birth to puberty in normal mice also induced serum gonadotropin and serum TSH, PRL, and GH reduction when the animals reached puberty.
[2]
Reference