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Details for phenotype: graft-versus-host disease
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EndoNet ID: ENP00451
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Name
graft-versus-host disease
General information
This phenotype is pathologic
Links to other resources
GO
regulation of leukocyte activation
MeSH term
D006086
Disease database
5388
Phenotype triggers
more activity (high ligand concentration, overexpression) of
PRLR
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in
immune_system
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Prolactin is released by mononuclear leucocytes and is involved in lymphocyte activation. It plays a hitherto unrecognized role in the pathogenesis of GVHD in humans.
[1]
Prolactin has been shown to be increased in and to effect a number of autoimmune states, such as graft-versus-host disease.
[1]
Reference
