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Details for phenotype: abdominal obesity-metabolic syndrome

EndoNet ID: ENP00470


abdominal obesity-metabolic syndrome

General information

This phenotype is pathologic

Links to other resources

OMIM 605552
Medline Plus 007290
MeSH term D024821
Disease database 31955

Phenotype triggers

  • more activity (high ligand concentration, overexpression) of glucocorticoid receptor
    in macrophage
    • Glucocorticoids play a role in adipocyte maturation, function and distribution. Differentiating adipocytes produce increasing levels of the enzyme 11-beta-hydroxysteroid dehydrogenase 1 to convert inactive cortisone into cortisol, in turn amplifying local glucocorticoid levels. [1]
    • Many findings implicate macrophages, GR and 11βHSD1 in the pro-inflammatory phenotype of metabolic dysfunction. [2]