Details for phenotype: abdominal obesity-metabolic syndrome

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EndoNet ID: ENP00470

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Name

abdominal obesity-metabolic syndrome

General information

This phenotype is pathologic

Links to other resources

GO	response to insulin stimulus
OMIM	605552
Medline Plus	007290
MeSH term	D024821
Disease database	31955

Phenotype triggers

• more activity (high ligand concentration, overexpression) of glucocorticoid receptor ui-button
  in macrophage ui-button
  • Glucocorticoids play a role in adipocyte maturation, function and distribution. Differentiating adipocytes produce increasing levels of the enzyme 11-beta-hydroxysteroid dehydrogenase 1 to convert inactive cortisone into cortisol, in turn amplifying local glucocorticoid levels. [1]
  • Many findings implicate macrophages, GR and 11βHSD1 in the pro-inflammatory phenotype of metabolic dysfunction. [2]

EndoNet at the Institut for Bioinformatics UMG Göttingen