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Details for phenotype: production of molecular mediator involved in inflammatory

EndoNet ID: ENP00471


production of molecular mediator involved in inflammatory

General information

This phenotype is not pathologic

Links to other resources

MeSH term 68007249

Phenotype triggers

  • more activity (high ligand concentration, overexpression) of mineralcorticoid receptor
    in macrophage
    • Inflammation may be a key mechanism translating MR signalling into cardiac and vascular remodelling. [1]
    • Mineralocorticoid/salt-induced pathology is characterised by an early vascular inflammatory response with elevated cardiac expression of inflammatory mediators such as monocytes/macrophages, MCP-1 and adhesion molecules (ICAM-1 and VCAM-1), prior to the onset of collagen deposition. [2]
    • mineralocorticoid/salt treatment is also associated with increased monocyte/macrophage infiltration and expression of inflammatory markers such as osteopontin, MCP-1, IL-6 and IL-1β in the kidney. [3]
    • MR antagonism prevents inflammation-induced peritoneal fibrosis and reduces macrophage infiltration and expression of MCP-1, TGF-β, PAI-1 and Sgk-1. [4]