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Details for phenotype: hypertension

EndoNet ID: ENP00475



General information

This phenotype is pathologic
  • Glucocorticoid-induced elevation in blood pressure is well documented in humans. [1]

Links to other resources

OMIM 145500
Medline Plus 000468
MeSH term D006973
Disease database 6330

Phenotype triggers

  • more activity (high ligand concentration, overexpression) of glucocorticoid receptor
    in macrophage
    • Oxidative stress and nitric oxide deficiency are emerging as key components in the pathogenesis of glucocorticoid-induced hypertension. [2]
    • This highlights the role of inflammation and oxidative stress in the pathogenesis of glucocorticoid-induced hypertension and this is consistent with a role for macrophages in this pathology. [3]
  • more activity (high ligand concentration, overexpression) of mineralcorticoid receptor
    in macrophage
    • Activation of an MR, in the context of inappropriate sodium status, has major cardiovascular pathophysiological consequences including hypertension. [3]
    • Chronic inappropriate activation of an MR is well recognised to promote hypertension. Excess plasma mineralocorticoids promote sodium and water retention and potassium secretion leading to the maintenance of blood pressure at a higher set point. [4]
    • MR antagonists have been shown to be effective anti-hypertensive agents in essential hypertension, suggesting a role for MR signalling in hypertension. [5]