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Details for phenotype: embryonic digestive tract development

EndoNet ID: ENP00525


embryonic digestive tract development

General information

This phenotype is not pathologic

Links to other resources

MeSH term 68038081

Phenotype triggers

  • normal activity of activin receptor type 2B
    in pancreatic_islets
    • Activins, members of the transforming growth factor-β (TGF-β) superfamily, govern embryonic axial patterning. [1]
    • ActRIIB-mediated signaling controls both AP pattern of the axial skeleton and lateral asymmetry of heart and lungs. [2]
    • Both ActRIIA and ActRIIB are expressed in the primordia of foregut organs, including lungs, stomach, intestines, and pancreas. [3]
    • Type II activin receptors are crucial for normal development of many foregut organs, and these receptors have a particularly critical role in development and function of the endocrine pancreas. [4]