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Statistic
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Details for phenotype: embryonic digestive tract development
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EndoNet ID: ENP00525
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Name
embryonic digestive tract development
General information
This phenotype is not pathologic
Links to other resources
GO
embryonic digestive tract development
MeSH term
68038081
Phenotype triggers
normal activity of
activin receptor type 2B
ui-button
in
pancreatic_islets
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Activins, members of the transforming growth factor-β (TGF-β) superfamily, govern embryonic axial patterning.
[1]
ActRIIB-mediated signaling controls both AP pattern of the axial skeleton and lateral asymmetry of heart and lungs.
[2]
Both ActRIIA and ActRIIB are expressed in the primordia of foregut organs, including lungs, stomach, intestines, and pancreas.
[3]
Type II activin receptors are crucial for normal development of many foregut organs, and these receptors have a particularly critical role in development and function of the endocrine pancreas.
[4]
Reference
