Details for phenotype: regulation of bone resorption

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EndoNet ID: ENP00551

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Name

regulation of bone resorption

General information

This phenotype is not pathologic

Links to other resources

GO	regulation of bone resorption
MeSH term	68001862

Phenotype triggers

• normal activity of vitronectin receptor ui-button
  in osteoclast ui-button
  • The colocalization of vitronectin receptor and vinculin in podosome-like structures may indicate its role in the attachment of resting and migrating osteoclasts to bone surface. [1]
• more activity (high ligand concentration, overexpression) of CaSR ui-button
  in osteoclast ui-button
  • The activation of CaSR leads to the down-regulation of osteoclastic activity. [2]

EndoNet at the Institut for Bioinformatics UMG Göttingen