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Details for phenotype: regulation of bone resorption

EndoNet ID: ENP00551


regulation of bone resorption

General information

This phenotype is not pathologic

Links to other resources

MeSH term 68001862

Phenotype triggers

  • normal activity of vitronectin receptor
    in osteoclast
    • The colocalization of vitronectin receptor and vinculin in podosome-like structures may indicate its role in the attachment of resting and migrating osteoclasts to bone surface. [1]
  • more activity (high ligand concentration, overexpression) of CaSR
    in osteoclast
    • The activation of CaSR leads to the down-regulation of osteoclastic activity. [2]