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Details for phenotype: proprioception

EndoNet ID: ENP00571

Name

proprioception

General information

This phenotype is not pathologic

Links to other resources

GO
MeSH term 68011434

Phenotype triggers

  • normal activity of trkC
    in dorsal_root_ganglion
    • TrkC deficient mice display abnormal movements that are athetotic in nature and result in highly abnormal limb postures. This suggests a defect in proprioception, the sensory function that localizes the limbs in space. [1]
    • Neurotrophin signaling through trk receptors is important in the development and maintenance of the mammalian nervous system. [2]
    • Mice lacking trkC have a loss of DRG neurons, this defect might be amongst other responsible for the abnormal movements. [2]
Reference