Status
Please wait ...
EndoNet
The information resource about the endocrine network in human.
Search
Search a component
Browse
Browse pathways
Browse hormones
Browse hormones functions
Browse hormone classification
Browse receptors
Network
Load network
Path analysis
Process network
Help
Help
Statistic
About
Details for phenotype: Pruritus
Top
General information
Triggers
Toolbox
Click to access the toolbox
Top
General information
Triggers
Toolbox
Click to access the toolbox
EndoNet ID: ENP00574
Add to network
Name
Pruritus
General information
This phenotype is pathologic
Links to other resources
GO
regulation of immune response
Medline Plus
003217
MeSH term
D011537
Disease database
25363
Phenotype triggers
normal activity of
Transient receptor potential cation channel subfamily V member 1
ui-button
in
mast_cell
ui-button
Vanilloid receptor subtype 1 (VR1) is an important regulator of the cutaneous neuroimmune system.
[1]
Direct activation of VR1 on mast cells may lead to the release of mast cell mediators which then are able to induce pruritus by binding to histamine- and proteinase-activated-2 (PAR-2) receptors on sensory nerve fibers.
[1]
Reference
