Details for phenotype: actin-mediated cell contraction

EndoNet ID: ENP00637

Name

actin-mediated cell contraction

This phenotype is not pathologic

GO	actin-mediated cell contraction
MeSH term	68055166

normal activity of ETA-R
in lipocyte_of_liver
- Interactions between endothelin-1 and hepatic stellate cells induces contractility of stellate cells from normal and cirrhotic rat liver. [1]
- Endothelin-A and endothelin-B receptor antagonist reduces portal pressure in portal hypertensive animals, consistent with its inhibitory effect on stellate cell contraction. [1]
- Stellate cell contractility increases with progressive liver injury and is proportional to the degree of stellate cell activation, becoming most prominent in the cirrhotic liver. Endothelin-stimulated contraction of stellate cells in cirrhotic liver may contribute to increased intrahepatic resistance and portal pressure. [1]
normal activity of ETB-R
in lipocyte_of_liver
- Interactions between endothelin-1 and hepatic stellate cells induces contractility of stellate cells from normal and cirrhotic rat liver. [1]
- Endothelin-A and endothelin-B receptor antagonist reduces portal pressure in portal hypertensive animals, consistent with its inhibitory effect on stellate cell contraction. [1]
- Stellate cell contractility increases with progressive liver injury and is proportional to the degree of stellate cell activation, becoming most prominent in the cirrhotic liver. Endothelin-stimulated contraction of stellate cells in cirrhotic liver may contribute to increased intrahepatic resistance and portal pressure. [1]

Reference