Details for phenotype: regulation of cardiac myocyte metabolism

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EndoNet ID: ENP00649

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Name

regulation of cardiac myocyte metabolism

General information

This phenotype is not pathologic

Links to other resources

GO	regulation of heart contraction cardiac muscle hypertrophy regulation of apoptosis
MeSH term	68006321

Phenotype triggers

• normal activity of leptin receptor ui-button
  in heart ui-button
  • Leptin can regulate the baseline physiology of the heart, including myocyte contractility, hypertrophy, apoptosis and metabolism. [1]
  • Db/db mouse has abnormal left ventricular function in vivo, with impaired glucose uptake during ischemia, leading to increased myocardial damage. [2]
  • Although the hearts of glucose-intolerant ob/ob mice are capable of maintaining their function under conditions of increased fatty acid supply and hyperinsulinemia, they are insulin-resistant, metabolically inefficient, and unable to modulate substrate utilization in response to changes in insulin and fatty acid supply. [3]

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