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Statistic
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Details for phenotype: positive regulation of smooth muscle cell migration
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EndoNet ID: ENP00654
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Name
positive regulation of smooth muscle cell migration
General information
This phenotype is not pathologic
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GO
positive regulation of smooth muscle cell migration
MeSH term
68002465
Phenotype triggers
normal activity of
Lysophosphatidic acid receptor 2
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in
smooth_muscle_cell
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LPA induces the proliferation and migration of vascular smooth muscle cells (VSMCs).
[1]
LPA1 and LPA2 were found to exhibit opposing effects on primary VSMCs derived from knockout mice. The migration of SMCs was increased in Lpar1−/− mice but attenuated in Lpar1−/−/Lpar2−/− mice, thus identifying LPA1 and LPA2 as negative and positive chemotactic mediators, respectively.
[2]
Reference
