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Statistic
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Details for phenotype: regulation of water loss via skin
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EndoNet ID: ENP00711
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Name
regulation of water loss via skin
General information
This phenotype is not pathologic
Links to other resources
GO
regulation of water loss via skin
Phenotype triggers
normal activity of
ER-alpha
ui-button
in
epidermis
ui-button
The positive effects of estrogens on the water content of the skin, that were observed in all patients, may be due to dermal and epidermal components. The estrogen-stimulated increases of acid mucopolysaccharides and of hyaluronic acid contribute to an increase water content in the dermis. The increased epidermal water content may be due to increased epidermal skin thickness with subsequently elevated amounts of a natural moisturizing factor.
[1]
normal activity of
ER-beta
ui-button
in
epidermis
ui-button
The positive effects of estrogens on the water content of the skin, that were observed in all patients, may be due to dermal and epidermal components. The estrogen-stimulated increases of acid mucopolysaccharides and of hyaluronic acid contribute to an increase water content in the dermis. The increased epidermal water content may be due to increased epidermal skin thickness with subsequently elevated amounts of a natural moisturizing factor.
[1]
Reference