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Details for phenotype: regulation of water loss via skin

EndoNet ID: ENP00711

Name

regulation of water loss via skin

General information

This phenotype is not pathologic

Links to other resources

GO

Phenotype triggers

  • normal activity of ER-alpha
    in epidermis
    • The positive effects of estrogens on the water content of the skin, that were observed in all patients, may be due to dermal and epidermal components. The estrogen-stimulated increases of acid mucopolysaccharides and of hyaluronic acid contribute to an increase water content in the dermis. The increased epidermal water content may be due to increased epidermal skin thickness with subsequently elevated amounts of a natural moisturizing factor. [1]
  • normal activity of ER-beta
    in epidermis
    • The positive effects of estrogens on the water content of the skin, that were observed in all patients, may be due to dermal and epidermal components. The estrogen-stimulated increases of acid mucopolysaccharides and of hyaluronic acid contribute to an increase water content in the dermis. The increased epidermal water content may be due to increased epidermal skin thickness with subsequently elevated amounts of a natural moisturizing factor. [1]
Reference