Details for phenotype: Supression of autoreactive B-lymphocytes

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EndoNet ID: ENP00767

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Name

Supression of autoreactive B-lymphocytes

General information

This phenotype is not pathologic

Links to other resources

Phenotype triggers

• Programmed cell death protein 1 ui-button
  in B-lymphocyte ui-button
  • PD-1 was identified as the main suppressor of auto-Ab formation (by autoreactive B-cells). [1]
  • We found that B-cells needed to express PD-1 and that T(regulatory)-cells needed to express PD-1 ligands, implying direct communication between T(regs) and B-cells. [1]

EndoNet at the Institut for Bioinformatics UMG Göttingen