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Details for phenotype: vascular relaxation

EndoNet ID: ENP00772

Name

vascular relaxation

General information

This phenotype is not pathologic

Links to other resources

Phenotype triggers

  • NPR1
    in smooth_muscle_cell
    • The ability of the cardiac natriuretic peptides to relax precontracted aortic rings requires NPR-A. [1]
    • ANP stimulation of NPR-A increases intracellular cGMP concentrations which leads after several steps to vascular smooth muscle relaxation. [1]
  • NPR2
    in smooth_muscle_cell
    • NPR-B is present in aortic vascular smooth muscle and mediates CNP relaxation of precontracted rat aorta. [1]
Reference